Shalina Healthcare

Rufedol

Rufedol is used for febrile states, inflammation, rheumatism and pain of various origins

• Tablets

Indications

Febrile states, inflammation, rheumatism, pain of various origins (dysmenorrhoea, dental pain, neuralgia, lumbago)

Pharmacological Class

Diclofenac : phenylacetic acid derivative.Paracetamol :para-aminophenol derivative

Pharmacological Properties

Anti-inflammatory, analgesic, antipyretic

Mechanism of Action

Diclofenac :
• Non-steroidal anti-inflammatories (NSAIDS) exert a potent blocking action on prostaglandin synthesis. During phagocytation of the immune complex by the leukocytes (the immune complex being formed by combining antigen-antibody + complements), prostaglandins arereleased on two levels : - direct release of prostaglandins as well as other phlogogenic substances (histamine, serotonin and kinins), which are the cause of acute vascular inflammation phenomena. - indirect release of prostaglandins by enzymes such a
• NSAIDs also exert an inhibiting activity on platelet aggregation. Paracetamol
• Peripheral analgesic
• Centrally acting antipyretic on the hypothalamus thermal control centre by inhibition of prostaglandin synthesis

Side Effects

Diclofenac : gastro-intestinal disorders, nausea, diarrhoea, epigastric pain. Paracetamol : Rare

Contradictions

Diclofenac : absolute : gastroduodenal ulcer, severe hepato-cellular insufficiency, severe renal insufficiency, children under 15 years, pregnancy (from 6th month) and lactation. Relative : patients receiving oral anticoagulants, combination with other NSAIDs. Paracetamol : - allergy to paracetamol.- hepato-cellular insufficiency

Observations

None