Shalina Healthcare

Ketazol

Ketazol is used in the treatment of fungal infection by sensitive organisms

• Shampoo

• Cream

• Tablets

Indications

Limited to fungal infection by sensitive organisms. Tablets :
• Systemic or visceral infections.
• Cutaneomucosal infections where these infections cannot be treated due to the extent of the lesions or in case of resistance to the usual antifungal treatments.
• Prevention of fungal infections in patients with congenital or acquired immune depression. Cream : Candidiasis,dermatophytes,pityriasis versicolor, erythrasma

Pharmacological Class

Imidazole derivative.

Pharmacological Properties

Antifungal.

Mechanism of Action

Operates at several levels in organisms
• Membrane (increased permeability)
• Cytoplasm (inhibition of oxidation processes in the mitochondria)
• Nucleus (inhibition of RNA synthesis)

Side Effects

• Hepatotoxicity
• Nausea, vomiting, diarrhoea
• Pruritus, skin rash, urticaria.
• Headache, dizziness.

Contradictions

Absolute : Allergy to ketoconazole and antifungals of the imidazole group.
• Alcohol, midazolam (interaction)
• Interaction : astemizole, cisapride, terfenadine, ebastine, triazolam.Relative :
• Pregnancy or lactation

Observations

• The dosage specified above should be continued without interruption for at least one week once the symptoms have disappeared and until all the cultures prove negative
• The penetration of ketoconazole into the CSF and brain tissues is low. Consequently, ketoconazole can not be used to treat meningitis
• The use of antacids should be delayed by 2 hours (risk of reduced absorption of ketoconazole)
• Patients who have exhibited allergic or hypersensitivity reactions after topical administration of imidazole derivatives should not be treated with oral ketoconazole