Shalina Healthcare

Napril

Napril is used to treat hypertension and other conditions

• Tablets

Indications

• Essential Hypertension (all grades)
• Reno vascular hypertension
• Congestive Cardiac Failure
• As an adjunct in management of Congestive Heart Failure

Pharmacological Class

Orally active ACE inhibitor.

Pharmacological Properties

Antihypertensive.

Mechanism of Action

• Napril 5/10 tablets, after desertification into the active enalaprilat, inhibits angiotensin-converting enzyme (ACE) which suppresses renin-angiotensin-aldosterone system and hence lowers the blood pressure
• Enalapril Maleate is antihypertensive even in patients with low-renin hypertension

Side Effects

• This medication may cause nausea, rash, persistent cough, muscle cramps, dizziness, headache, angiodema & renal failure.
• Decrease in haemoglobin, red blood corpuscles and platelets, angioneurotic edema

Contradictions

• Napril 5/10 tablets is contraindicated in patients who are hypersensitive to this product and in patients with a history of angioedema related to previous treatment with an angiotensin converting enzyme inhibitor and in patients with hereditary or idiopathic angioedema
• Contraindicated in pregnancy, nursing mothers
• With diuretics hypotensive action is potentiated. May increase lithium levels
• Risk of bone marrow suppression increased with concomitant therapy with immunosuppressive drugs (cyclophosphamide, azathioprine)
• NSAIDs blunt its hypotensive effect

Observations

• Should not be refrigerated
• Keep in a dark place
• Keep out of the reach of children