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| Indications |
General : Ketalin can be used as :
• A single anaesthetic agent; particularly suited to short operations. With repeated injections or when used as an I.V. infusion, prolonged anaesthesia can be achieved for several hours
• An inducer of anaesthesia before the administration of other anaesthetic agents
• Potentiates mild anaesthetics, such as nitrogen protoxyde.
Obstetric :Ketalin can be used alone or in combination with other anaesthetics
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| Pharmacological Class |
Phenciclidine derivative
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| Pharmacological Properties |
General anaesthetic
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| Mechanism of Action |
When administered parenterally, ketamine causes a state known as dissociative anaesthesia, marked by rapid anaesthesia and significant analgesia. This state is due partly to blocking of the influx of sensory impulses in the thalamus and associated areas in the cortex and partly to limbic stimulation
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| Side Effects |
• Increase in blood pressure, heart rate and intracranial and intraocular pressure
• Confusional states with hallucinations
• Possibility of diplopia, eye movements and nystagmus rendering intraocular surgery dangerous
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| Contradictions |
• Blood or intracranial pressure
• Known hypersensitivity to ketamine
• Previous mental disorders
• Severe cardiac insufficiency
• Alcoholism, asthma, hyperthyroidism
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| Observations |
Due to chemical incompatibility, do not combine barbiturates and ketamine in the same syringe
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