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| Indications |
Amoebiasis, trichomonasis, lambliasis, candidiasis, anaerobic organism infections
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| Pharmacological Class |
Nitro-imidazole derivative
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| Pharmacological Properties |
Active on amoeba, trichomonas, candida and bactericidal on gram+ and gram- anaerobic organisms
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| Mechanism of Action |
Taken orally, it is rapidly absorbed. Its diffusion in the tissue is excellent and broad
• Contact amoebicide in the digestive tract
• Tissue amoebicide in liver, lung, kidneys. Its mechanism of action involves interference with DNA by a metabolite in which the nitro group of Metronidazole has been reduced
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| Side Effects |
Rare : nausea, vomiting, dizziness
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| Contradictions |
Hypersensitivity to imidazoles
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| Observations |
• It is active on vegetation forms in the intestine and elsewhere
• The effect on cystic forms of Entamoeba histolytica is less than perfect (30 to 40% failure rate)
• Pessaries containing 500mg of metronidazole are available for use in combination with tablets in case of trichomonas vaginalis
• The consumption of alcohol is prohibited during treatment with metronidazole : inhibition of alcohol catabolism (Antabuse effect)
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