Shalina Healthcare

Ibucap

Ibucap is popular for the treatment of pain disorders, including dental pain, headache, neuralgia and rheumatism

• Capsules

Indications

• Pain disorders, dental pain, headache, neuralgia, dysmenorrhoea Febrile states. Rheumatism (rheumatoid polyarthritis, ankylosing spondylarthritis)

Pharmacological Class

Ibuprofen : propionic acid derivative.Caffeine : alkaloid of the xanthin group.Paracetamol : para-aminophenol derivative

Pharmacological Properties

Analgesic, antipyretic, anti-inflammatory

Mechanism of Action

• Analgesic, antipyretic : inhibition of the cyclo-oxygenase and prostaglandin synthesis
• Anti-inflammatory : inhibition of prostaglandin synthesis. Paracetamol : peripheral analgesic centrally acting antipyretic on the hypothalamus thermal control centre by inhibition of prostaglandin synthesis. Caffeine : produces a vasoconstrictor effect that acts on the painful distension of cranial blood vessels

Side Effects

• Buprofen : gastrointestinal effects, nausea, vomiting, stomach pain, dizziness, headache.
• Caffeine : excitation, insomnia, palpitations
• Paracetamol : rare (except sometimes skin rash allergy)

Contradictions

Proven allergy to ibuprofen, active gastroduodenal ulcer, severe hepato-cellular insufficiency, severe renal insufficiency, pregnancy (from 6th month), lactation

Observations

• Food delays the absorption of ibuprofen. During the 3rd trimester all the prostaglandin synthesis inhibitors may expose :- The fetus to cardio-pulmonary toxicity - The mother and child at the end of pregnancy to prolonged bleeding time.
• Do not combine IBUCAP to ciprofloxacin or norfloxacin : risk of reduction of hepatic catabolism of the caffeine