Shalina Healthcare

Anaflam

Anaflam is used in the treatment of pain, including dental pain, headache, neuralgia, dysmenorrhoea. febrile states and rheumatism

• Tablets

• Syrup

Indications

Pain disorders, dental pain, headache, neuralgia, dysmenorrhoea. febrile states, rheumatism (rheumatoid polyarthritis, ankylosing spondylarthritis)

Pharmacological Class

• Ibuprofen : propionic acid derivative.
• Paracetamol : Para-aminophenol derivative

Pharmacological Properties

Anti-inflammatory, Antipyretic

Mechanism of Action

Ibuprofen :
• Analgesic, antipyretic : inhibition of cyclo-oxygenase and prostaglandin synthesis
• Anti-inflammatory : inhibition of prostaglandin synthesis. Paracetamol:
• Peripheral analgesic
• Centrally acting antipyretic on the hypothalamus thermal control centre by inhibition of prostaglandin synthesis

Side Effects

Ibuprofen : gastro-intestinal effects, nausea, vomiting, stomach pain, dizziness, and headache. Paracetamol : rare (except skin rash allergies)

Contradictions

• Established allergy to ibuprofen, active gastroduodenal ulcer, severe hepato-cellular insufficiency, severe renal insufficiency, pregnancy, (from 6th month), lactation.

Observations

• Food delays the absorption of ibuprofen.
• During the 3rd trimester, all the prostaglandin synthesis inhibitors can expose : -The foetus to cardiopulmonary toxicity. -The mother and child at the end of pregnancy to potential prolonged bleeding time