Rufedol

Rufedol is used for pain and inflammation, rheumatism and pain of various origins. Rufedol is used for the treatment of mild to moderate pain

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Indications
Pain and inflammation associated with musculoskeletal and joint disorders like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and fever.

Pharmacological Class
Diclofenac: benzene-acetic acid derivative. Paracetamol: para-aminophenol derivative.

Pharmacological Properties
Anti-inflammatory, analgesic, antipyretic

Mechanism of Action
Diclofenac Inhibits cyclooxygenase (COX)-1 and COX-2, thereby inhibiting prostaglandin synthesis. May also inhibit neutrophil aggregation/activation, inhibit chemotaxis, decrease proinflammatory cytokine level, and alter lymphocyte activity

Paracetamol: exhibits analgesic action of peripheral blockage of pain impulse generation. It produces antipyresis by inhibiting the hypothalamic heat regulating centre. Its weak anti-inflammatory activity is related to inhibition of prostaglandin synthesis in the CNS.

Side Effects
GI disturbances, nephrotic syndrome, epigastric pain, nausea, vomiting, diarrhea, hepatitis, rash, pruritus, wheezing, bronchospasm, prolonged bleeding time.

Contraindications
Hypersensitivity, active peptic ulcer or GI bleeding, history of allergic responses to aspirin or other NSAIDs, acute porphyria.

Observations
None