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Anaflam

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Anaflam

Anaflam is used in the treatment of pain, including dental pain, headache, neuralgia, dysmenorrhoea, febrile states and rheumatism.
Product Molecule
Anaflam Tablet
Ibuprofen, Paracetamol
Anaflam Syrup
Ibuprofen, Paracetamol
Indications
Pain and inflammation associated with musculoskeletal and joint disorders.
Pharmacological Class
Ibuprofen: propionic acid derivative. Paracetamol: para-aminophenol derivative.
Pharmacological Properties
Anti-inflammatory, Antipyretic.
Mechanism Of Action
Ibuprofen: Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclo-oxygenase (COX) isoenzymes, COX-1 and COX-2. May inhibit chemotaxis, alter lymphocyte activity, decrease proinflammatory cytokine activity, and inhibit neutrophil aggregation; these effects may contribute to anti-inflammatory activity. Paracetamol: Exhibits analgesic action by peripheral blockage of pain impulse generation. It produces antipyresis by inhibiting the hypothalamic heat regulating centre. Its weak anti-inflammatory activity is related to inhibition of prostaglandin synthesis in the CNS.
Side Effects
Dyspepsia, heart burn, GI bleeding, rash, asthmatic attacks, thrombocytopenia, drug induced ulcer, drowsiness, hepatic necrosis, renal papillary necrosis, vision disturbances & disorientation; rarely nausea & vomiting can occur.
Contraindications
Active peptic ulcer, history of hypersensitivity to either component, recent GI bleeding, neonates.
Observations
Food interferes with the rate of Ibuprofen absorption.
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