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Betasol

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Betasol

Betasol is used for specific indications where topical corticosteroid therapy is considered the best treatment for contact eczema, atopic dermatitis & lichen
Product Molecule
Betasol Cream
Clobetasol Propionate
Betasol Lotion
Clobetasol Propionate
Indications
For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. In the treatment of moderate to severe plaque-type psoriasis.
Pharmacological Class
Corticosteroid.
Pharmacological Properties
Anti-inflammatory, Antiallergic, Antipruritic.
Mechanism Of Action
Clobetasol propionate has anti-inflammatory, antipruritic, and vasoconstrictive properties. Corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
Side Effects
Perioral dermatitis, striae especially in flexures. Dermal and epidermal atrophy especially on the face, steroid purpura. Prolonged usage of large amount of clobetasol propionate can lead to sufficient systemic levels to produce adrenal suppression, Cushing's syndrome, diabetes and hypertension.
Contraindications
Children
Observations
An increase in the number of daily applications may worsen the undesirable effects without improving the therapeutic effects. The total dosage should not exceed 50 gm per week. Treatment beyond 4 consecutive weeks is not recommended. If concomitant skin infections are present or develop, an appropriate antifungal or antibacterial agent should be used.
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