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Diproson

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Diproson

Diproson is used where topical corticosteroid therpay is considered the best treatment: contact eczema, atopic dermatitis, lichen planus
Product Molecule
Diproson Lotion
Betamethasone Dipropionate
Diproson Cream
Betamethasone Dipropionate
Indications
Relief from inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. In the treatment of moderate to severe plaque-type psoriasis. Allergic and inflammatory disorders.
Pharmacological Class
Corticosteroid.
Pharmacological Properties
Anti-inflammatory, antipuritic, antiallergic.
Mechanism Of Action
Betamethasone dipropionate has anti-inflammatory, antipruritic, and vasoconstrictive properties. Corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
Side Effects
Dermal atrophy, local irritation, folliculitis, hypertrichosis. Abrupt withdrawal leading to acute adrenal insufficiency manifesting as malaise, weakness, mental changes, muscle and joint pains, dystonia, hypoglycaemia, hypotension, dehydration and death.
Contraindications
Hypersensitivity; systemic fungal or acute infections.
Observations
An increase in the number of daily applications may worsen the undesirable effects without improving the therapeutic effects. The total dosage should not exceed 50gm per week. Patients should not be treated for more than 2 weeks at a time. If concomitant skin infections are present or develop, an appropriate antifungal or antibacterial agent should be used.
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