Erycin

Posted September 27, 2018

Erycin

Erycin contains Erythromycin is one of the most widely used antibiotics, Erythromycin belongs in a group of drugs called macrolide antibiotics

Product	Molecule
Erycin Tablets	Erythromycin

Molecule: Erythromycin

Formulation: Erythromycin 500mg Tablets

Packaging Unit: 10X10 Tablets

Dosage: Adults: 250 mg tablet four times daily in equally spaced doses or one 500 mg tablet every 12 hours. Dosage may be increased up to 4 g per day according to the severity of the infection. However, twice-aday dosing is not recommended when doses larger than 1 g daily are administered. Children: The usual dosage is 30 to 50 mg/kg/day, in equally divided doses. For more severe infections this dosage may be doubled but should not exceed 4 g per day.

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Indications

Mild to moderate Upper and lower respiratory tract infections caused by Streptococcus pyogenes; Streptococcus pneumonia. Listerosis, pertussis, skin & skin structure infections, diphtheria, intestinal amoebiasis, acute pelvic inflammatory disease.

Pharmacological Class

Antibiotic: Macrolide.

Pharmacological Properties

Antibiotic

Mechanism Of Action

Erythromycin acts by inhibition of protein synthesis by binding 50 S ribosomal subunits of susceptible organisms.

Side Effects

Rash, urticaria; nausea, vomiting, GI discomfort; ototoxicity; central neurotoxicity; agranulocytosis; arrhythmias; pancreatitis. Potentially Fatal: Hepatotoxicity, cholestatic jaundice; raised serum transaminases; eosinophilia.

Contraindications

Erythromycin is contraindicated in patients with known hypersensitivity to this antibiotic, porphyria, hepatic impairment, pregnancy

Observations

Should be taken on an empty stomach. (Best taken on an empty stomach at least 2 hours before meals). May antagonise therapeutic effects of lincomycin and clindamycin. Concurrent usage may lead to increased absorption of alcohol. Potentially Fatal: May potentiate actions of neuromuscular blockers, oral anticoagulants, ciclosporin, theophylline. Terfenadine, astemizole, cisapride toxicity increased.