Ketazol is used to treat skin infections such as athlete's foot, jock itch, ringworm, and certain kinds of dandruff
Formulation: Ketaconazole 2% wlw Cream
Packaging Unit: 15/30gm Cream
Dosage: Skin fungal infections as 2% cream: Apply 1-2 times daily to cover affected and surrounding area until at least a few days after disappearance of symptoms.
Formulation: Ketaconazole 2% wlv Shampoo
Packaging Unit: 100ml Shampoo
Dosage: Apply twice a week for first four weeks and thereafter once a week or as directed by physician
Formulation: Ketoconazole 200mg Tablets
Packaging Unit: 10 Tablets
Dosage: Adults: 200 mg once daily. Increase to 400 mg once daily if clinical response is insufficient. Treatment duration: 14 days and for at least 1 week after symptoms have cleared. Children: ≥ 2 yr: 3.3-6.6 mg/kg daily as a single dose. Treatment duration: 1-2 weeks for candidiasis; at least 4 weeks in recalcitrant dermatophyte infections and up to 6 months for other systemic mycoses.
Candiasis, recalcitrant dermatophyte infections, systemic mycoses, chronic vaginal candidiasis. Cream: Candidiasis, dermatophytes, seborrhoeic dermatitis.
Mechanism Of Action
Ketoconazole interferes with biosynthesis of triglycerides and phopholipids by blocking fungal cytochrome P-450, thus altering cell membrane permeability in susceptible fungi. It also inhibits other fungal enzymes resulting in the accumulation of toxic concentrations of hydrogen peroxide.
GI disturbances e.g. nausea and vomiting; rash, dermatitis, burning sensation, pruritus; headache, dizziness, somnolence, fever and chills; thrombocytopenia; gynaecomastia, impotence; raised intracranial pressure; photophobia; transient elevations in LFTs.
Hypersensitivity; preexisting liver disease, porphyria. Concurrent use with cisapride, terfenadine or astemizole.
Should be taken with food. Reduced absorption with antimuscarinics, antacids, H2-blockers, PPIs, sucralfate. Dose should be delayed by 2 hours.