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Ketazol

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Ketazol

Ketazol is used to treat skin infections such as athlete's foot, jock itch, ringworm, and certain kinds of dandruff
Product Molecule
Ketazol Cream
Ketaconazole
Ketazol Shampoo
Ketaconazole
Ketazol Tablets
Ketoconazole
Indications
Candiasis, recalcitrant dermatophyte infections, systemic mycoses, chronic vaginal candidiasis. Cream: Candidiasis, dermatophytes, seborrhoeic dermatitis.
Pharmacological Class
Imidazole derivative.
Pharmacological Properties
Antifungal
Mechanism Of Action
Ketoconazole interferes with biosynthesis of triglycerides and phopholipids by blocking fungal cytochrome P-450, thus altering cell membrane permeability in susceptible fungi. It also inhibits other fungal enzymes resulting in the accumulation of toxic concentrations of hydrogen peroxide.
Side Effects
GI disturbances e.g. nausea and vomiting; rash, dermatitis, burning sensation, pruritus; headache, dizziness, somnolence, fever and chills; thrombocytopenia; gynaecomastia, impotence; raised intracranial pressure; photophobia; transient elevations in LFTs.
Contraindications
Hypersensitivity; preexisting liver disease, porphyria. Concurrent use with cisapride, terfenadine or astemizole.
Observations
Should be taken with food. Reduced absorption with antimuscarinics, antacids, H2-blockers, PPIs, sucralfate. Dose should be delayed by 2 hours.
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