L-Artem / Shal’Artem


L-Artem / Shal'Artem

L-Artem tablets are indicated for the treatment of P. falciparum malaria cases resistant to both chloroquine and sulphadoxine pyrimethamine combination
Product Molecule
L-Artem Tablets
Artemether, Lumefantrine
L-Artem Dispersible Tablets
Artemether, Lumefantrine
L-Artem Dry Syrup
Artemether, Lumefantrine
L-Artem Forte Tablets
Artemether, Lumefantrine
Treatment of P. falciparum malaria cases resistant to both chloroquine and sulphadoxine pyrimethamine combination.
Pharmacological Class
Artemether: artemisinin derivative. Lumefantrine: synthetic aryl-amino alcohol derivative.
Pharmacological Properties
Multi drug resistent Antimalarial treatment
Mechanism Of Action
Artemether is concentrated in the food vacuole. It interacts with haem, blocking conversion to haemozoin, destroying existing haemozoin and releasing haem and a cluster of free radicals into the parasite. Lumefantrine is thought to interfere with the haem polymerisation process. Both Artemether and Lumefantrine have a secondary action involving inhibition of nucleic acid and protein synthesis within the malarial parasite. Artemether is fast acting drug with a short half-life. Lumefantrine acts slowly and has a longer half-life.
Side Effects
Headache, dizziness, sleep disorder, abdominal pain, anorexia, diarrhoea, vomiting, nausea, palpitation, cough, arthralgia, myalgia, pruritus, rash, asthenia and fatigue. Somnolence, involuntary muscle contractions, paraesthesia, hypoaesthesia, abnormal gait, ataxia.
In those with hypersensitivity to the active substances or any of the excipients. In the first trimester of pregnancy.
Driving and use of machinery is not recommended due to risk of dizziness and fatigue/asthenia. Artemether and Lumefantrine tablets should be taken with high fat food or drinks such as milk. Use with caution in patients with severe hepatic or renal insufficiency and patients refusing food intake.

Recent Posts