Lopeshal / Loprade

Posted September 23, 2018

Lopeshal / Loprade

Lopeshal is used in the symptomatic treatment of acute and chronic diarrhoea. Lopeshal slows the rhythm of digestion

Product	Molecule
Lopeshal Tablets	Loperamide Hydrochloride

Molecule: Loperamide Hydrochloride

Formulation: Loperamide Hydrochloride 2mg Tablets

Packaging Unit: Lopeshal: 25 x 6 Tablets

Dosage: Adult - The recommended initial dose is 4 mg followed by 2 mg after each unformed stool. Children - Two to five years (13 to 20Kg): 1mg t.i.d. (3mg daily dose),

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Indications

Lopeshal is indicated for the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease. Lopeshal is also indicated for reducing the volume of discharge from ileostomies.

Pharmacological Class

Pharmacological Properties

Mechanism Of Action

Loperamide hydrochloride acts by slowing intestinal motility and by affecting water and electrolyte movement through the bowel. Lopeshal binds to the opiate receptor in the gut wall. Consequently, it inhibits the release of acetylcholine and prostaglandins, thereby reducing peristalsis and increasing intestinal transit time. Lopeshal increases the tone of the anal sphincter, thereby reducing incontinence and urgency.

Side Effects

Contraindications

Lopeshal is contraindicated in patients with a known hypersensitivity to Lopeshal or to any of the excipients, in patients with abdominal pain in the absence of diarrhea.

Observations