Maladox is an antimalarial schizonticide, used in the treatment of malaria. Pyrimethamine/sulfadoxine is an antimalarial agent
Molecule: Sulphadoxine, Pyrimethamine
Formulation: Sulphadoxine 500mg + Pyrimethamine 25mg Tablets
Packaging Unit: 50X3 Tablets
Dosage: Adults: The combination is recommended as single adult doses of 1500 mg of sulphadoxine drug plus 75 mg pyrimethamine (25 mg of the sulfa component per kg as a single dose). Children: 2 - 11 months - (5 - 10 Kg) Half tablet. 1 - 5 years - (10.1 - 20 Kg) One tablet. 6 - 8 years - (20.1 - 30 Kg) One and half tablet. 9 - 11 years - (30.1 - 40 Kg) Two tablets.
The combination is indicated for the treatment of Plasmodium falciparum malaria in those patients in whom chloroquine resistance is suspected.
Sulfadoxine: sulphonamide. Pyrimethamine: amino-pyrimidine derivative.
Mechanism Of Action
Sulphadoxine and pyrimethamine combination is an antimalarial agent which acts by reciprocal potentiation of its two components, achieved by a sequential blockade of two enzymes involved in the biosynthesis of folinic acid within the parasites.
Rare gastrointestinal disorders, allergic skin reactions, blood abnormalities.
The drug is contraindicated in patients with severe renal insufficiency, marked liver parenchymal damage or blood dyscrasias, hypersensitivity to pyrimethamine or sulphonamides, patients with documented megaloblastic anemia due to folate deficiency, infants < 2 months of age, pregnancy at term and during the nursing period.
Adequate fluid intake must be maintained in order to prevent crystalluria and stone formation. If anorexia or vomiting occurs during the therapy, these adverse effects may be minimized by taking the drug with meals. Instruct the patient to seek medical attention and discontinue prophylactic therapy if sore throat, fever, arthralgia, cough, shortness of breath, pallor, purpura, jaundice or glossitis develop.