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Metazol / Shalmet

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Metazol / Shalmet

Metazol contains Metronidazole used for the treatment of both protozoal infections and a variety of bacterial infections
Product Molecule
Metazol Syrup
Metronidazole
Metazol Tablets
Metronidazole
Metazol Infusion
Metronidazole, Sodium Chloride
Indications
Amoebiasis, trichomoniasis, giardiasis, candidiasis, anaerobic bacterial infections, intra-abdominal infections, gynaecological infections, bacterial septicaemia, meningitis, brain abscess, lower respiratory tract infections caused by Bacteriodes species.
Pharmacological Class
Metronidazole is an oral synthetic antiprotozoal and antibacterial agent.
Pharmacological Properties
Active on amoeba, trichomonas, candida and bactericidal on gram+ and gram- anaerobic organisms
Mechanism Of Action
Metronidazole is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms.
Side Effects
GI disturbances e.g. nausea, unpleasant metallic taste, vomiting, diarrhoea or constipation. Furred tongue, glossitis, and stomatitis due to overgrowth of Candida. Rarely, antibiotic-associated colitis. Weakness, dizziness, ataxia, headache, drowsiness, insomnia, changes in mood or mental state. Numbness or tingling in the extremities, epileptiform seizures (high doses or prolonged treatment). Transient leucopenia and thrombocytopenia. Hypersensitivity reactions. Urethral discomfort and darkening of urine. Raised liver enzyme values, cholestatic hepatitis, jaundice. Thrombophlebitis (IV).
Contraindications
History of hypersensitivity to metronidazole or other nitroimidazole derivatives. Pregnancy (1st trimester) and lactation.
Observations
Alcoholic beverages should be avoided while taking Metronidazole.

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