Misocol contains Chloramphenicol used for the treatment of typhoid fever. Chloramphenicol is a synthetic broadspectrum antimicrobial
Formulation: Chloramphenicol 1gm Injectables
Packaging Unit: 1gm Vial
Dosage: Parenteral : 1 to 4gm / 24 hours
Formulation: Chloramphenicol 250mg Capsules
Packaging Unit: 10X10 Capsules
Dosage: Adult: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections due to moderately resistant organisms. Continue treatment after the patient
Acute infections caused by Salmonella typhi. Serious infections caused by susceptible strains in accordance with the concepts expressed above: Salmonella species, H. influenzae, specially meningeal infections, Rickettsia, Lymphogranuloma-psittacosis group. Various gram-negative bacteria causing bacteremia, meningitis, or other serious gramnegative infections. Other susceptible organisms which have been demonstrated to be resistant to all other appropriate antimicrobial agents. Cystic fibrosis regimens.
Antibiotic : Chloramphenicol.
Mechanism Of Action
hloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase.
GI symptoms, bleeding, peripheral and optic neuritis, visual impairment, blindness, encephalopathy, confusion, delirium, mental depression, headache. Haemolysis in patients with G6PD deficiency. Ophthalmic application: Hypersensitivity reactions including rashes, fever and angioedema. Ear drops: Ototoxicity. Potentially Fatal: Bone marrow suppression and irreversible aplastic anaemia. Neutropenia, thrombocytopenia. Grey baby syndrome. Rarely, anaphylaxis.
History of hypersensitivity or toxic reaction to the drug; pregnancy, lactation; porphyria; parenteral administration for minor infections or as prophylaxis; pre-existing bone marrow depression or blood dyscrasias.
Chloramphenicol decreased effects of iron and vitamin B12 in anaemic patients. Phenobarbitone and rifampin reduce efficacy of chloramphenicol. Impairs the action of oral contraceptives.