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Moxyclav / Zanitin

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Moxyclav / Zanitin

Moxyclav contains a combination Amoxicillin is a semi-synthetic penicillin antibiotic and Clavulanic Acid a beta-lactamase inhibitor
Product Molecule
Moxyclav Injectables
Amoxicillin, Clavulanic Acid
Metazol Tablets
Metronidazole
Moxyclav Duo Tablets
Amoxicillin, Clavulanic Acid
Moxyclav Duo Syrup
Amoxicillin, Clavulanic Acid
Indications
Respiratory Tract Infections – caused by β-lactamase producing strains of H. influenzae and M. catarrhalis. Otitis Media – caused by β-lactamase producing strains of H. influenzae and M. catarrhalis. Sinusitis – caused by β-lactamase producing strains of H. influenzae and M. catarrhalis. Skin and Skin Structure Infections – caused by β-lactamase producing strains of S. aureus and E. coli. Urinary Tract Infections – caused by β-lactamase producing strains of E. coli, Klebsiella spp.
Pharmacological Class
Antibiotic : Beta Lactam, semi-synthetic penicillin.
Pharmacological Properties
Broad Spectrum antibiotic.
Mechanism Of Action
Amoxicillin is a semi-synthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative microorganisms. Amoxicillin inhibits cell wall synthesis leading to lysis of the bacterial cell. Amoxicillin is, however, susceptible to degradation by β-lactamases, and therefore, the spectrum of activity does not include organisms which produce these enzymes. Clavulanic acid is a β-lactamase inhibitor which possesses the ability to inactivate a wide range of β-lactamase enzymes commonly found in microorganisms resistant to penicillin and cephalosporins. In particular, it has good activity against clinically important plasmid mediated β-lactamases frequently responsible for drug resistance.
Side Effects
The most frequently reported adverse effects were diarrhea/loose stools, nausea, skin rashes and urticaria, vomiting and vaginitis. Other less frequently reported reactions include: Abdominal discomfort, flatulence, and headache.
Contraindications
MOXYCLAV is contraindicated in patients with a history of hypersensitivity to beta-lactams, e.g. penicillins and cephalosporins.
Observations
None

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