Napril

Posted September 24, 2018

Napril

Napril is an ACE inhibitor, Napril is used to treat high blood pressure (hypertension) and also used in the treatment of congestive heart failure in adults

Product	Molecule
Napril Tablets	Enalapril

Molecule: Enalapril

Formulation: Enalapril Maleate 5mg/10mg Tablets

Packaging Unit: 30 Tablets

Dosage: Hypertension Adult: Initially, 5mg at bedtime. Maintenance: 10-20mg once daily increased up to 40mg in divided doses in severe hypertension. Max: 40mg/day. Child: 80mcg/kg once daily. Elderly: May initiate at lower doses at 2.5mg daily. Heart failure Adult: Initially, 2.5mg daily. Maintenance: 20mg once daily as a single or in 2 divided doses, up to 40mg daily in 2 divided doses. Renal impairment: Initial dose should be halved.

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Indications

Hypertension, heart failure.

Pharmacological Class

ACE (Angiotensin converting enzyme) Inhibitor.

Pharmacological Properties

Antihypertensive.

Mechanism Of Action

Enalapril is de-esterified into the active enalaprilat resulting in potent inhibition of ACE thus leading to reduced levels of angiotensin II and aldosterone. Clinically, blood pressure is reduced, salt and water retention is corrected. Ventricular hypertrophy is reversed.

Side Effects

Initial hypotension may be severe and prolonged. Dizziness, headache, fatigue, persistent dry cough, abnormal taste, lassitude, rash, neutropenia, renal impairment or failure.

Contraindications

Hypersensitivity. history of angioedema due to previous treatment with ACE inhibitors; bilateral renal artery stenosis. Pregnancy.

Observations

May be taken with or without food.