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Paludose Plus

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Paludose Plus

Paludose Plus is used to treat uncomplicated falciparum malaria and vivax malaria, particularly in case of resistance to other antimalarials
Product Molecule
Paludose Plus Tablets
Dihydroartemisinine, Piperaquine
Indications
Paludose Plus is indicated for the treatment of uncomplicated Plasmodium falciparum malaria in adults and children.
Pharmacological Class
Pharmacological Properties
Mechanism Of Action
Paludose Plus is a synergistic combination of Dihydromisinin and Piperaquine; Dihydromisinin is able to reach high concentrations within the parasitized erythrocytes. Its endoperoxide bridge is thought to be essential for its antimalarial activity, causing free-radical damage to parasite membrane systems including: Inhibition of falciparum sarcoplasmic-endoplasmic reticulum calcium ATPase, Interference with mitochondrial electron transport Interference with parasite transport proteins Disruption of parasite mitochondrial function Piperaquine is a bisquinoline, and this class has shown good antimalarial activity against chloroquineresistant Plasmodium strains in vitro. The bulky bisquinolone structure may be important for activity against chloroquine- resistant strains, and may act through the following mechanisms: Inhibition of the transporters that efflux chloroquine from the parasite food vacuole Inhibition of haem-digestion pathway in the parasite food vacuole.
Side Effects
Contraindications
Hypersensitivity to any of the active substances or to any of the excipients.
Observations
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