Paludose Plus is used to treat uncomplicated falciparum malaria and vivax malaria, particularly in case of resistance to other antimalarials
Paludose Plus Tablets
Molecule: Dihydroartemisinine, Piperaquine
Formulation: Dihydroartemisinine 40mg + Piperaquine 320mg Tablets
Packaging Unit: 1X8 Tablets
Dosage: Dosage regimen is recommended depending on body weight on the basis of 2 mg/kg of Dihydromisinin and 16 mg/kg of Piperaquine Phosphate once a day for three days
Paludose Plus is indicated for the treatment of uncomplicated Plasmodium falciparum malaria in adults and children.
Mechanism Of Action
Paludose Plus is a synergistic combination of Dihydromisinin and Piperaquine; Dihydromisinin is able to reach high concentrations within the parasitized erythrocytes. Its endoperoxide bridge is thought to be essential for its antimalarial activity, causing free-radical damage to parasite membrane systems including:
Inhibition of falciparum sarcoplasmic-endoplasmic reticulum calcium ATPase,
Interference with mitochondrial electron transport
Interference with parasite transport proteins
Disruption of parasite mitochondrial function
Piperaquine is a bisquinoline, and this class has shown good antimalarial activity against chloroquineresistant Plasmodium strains in vitro. The bulky bisquinolone structure may be important for activity against chloroquine- resistant strains, and may act through the following mechanisms:
Inhibition of the transporters that efflux chloroquine from the parasite food vacuole
Inhibition of haem-digestion pathway in the parasite food vacuole.
Hypersensitivity to any of the active substances or to any of the excipients.