Diclofenac Inhibits cyclooxygenase (COX)-1 and COX-2, thereby inhibiting prostaglandin synthesis. May also inhibit neutrophil aggregation/activation, inhibit chemotaxis, decrease proinflammatory cytokine level, and alter lymphocyte activity Paracetamol: exhibits analgesic action of peripheral blockage of pain impulse generation. It produces antipyresis by inhibiting the hypothalamic heat regulating centre. Its weak anti-inflammatory activity is related to inhibition of prostaglandin synthesis in the CNS.

GI disturbances, nephrotic syndrome, epigastric pain, nausea, vomiting, diarrhea, hepatitis, rash, pruritus, wheezing, bronchospasm, prolonged bleeding time.