Rufedol

Posted September 23, 2018

Rufedol

Rufedol is used for pain and inflammation, rheumatism and pain of various origins. Rufedol is used for the treatment of mild to moderate pain

Product	Molecule
Rufedol Tablets	Diclofenac Sodium, Paracetamol
Rufedol Plus Tablets	Diclofenac Potassium, Paracetamol, Chloroxazone

Molecule: Diclofenac Sodium, Paracetamol

Formulation: Diclofenac Sodium 50mg + Paracetamol 500mg Tablets

Packaging Unit: 10X10 Tablets

Dosage: Adults: 1 tablet, 2-3 times a day.

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Molecule: Diclofenac Potassium, Paracetamol, Chloroxazone

Formulation: Diclofenac Potassium 50mg + Paracetamol 500mg + Chloroxazone 250mg Tablets

Packaging Unit: 10X10 Tablets

Dosage: Adults: 3 Tablets/day, in three divided doses, to be taken after meals or as directed by the physician.

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Indications

Pain and inflammation associated with musculoskeletal and joint disorders like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and fever.

Pharmacological Class

Diclofenac: benzene-acetic acid derivative. Paracetamol: para-aminophenol derivative.

Pharmacological Properties

Anti-inflammatory, analgesic, antipyretic

Mechanism Of Action

Diclofenac Inhibits cyclooxygenase (COX)-1 and COX-2, thereby inhibiting prostaglandin synthesis. May also inhibit neutrophil aggregation/activation, inhibit chemotaxis, decrease proinflammatory cytokine level, and alter lymphocyte activity Paracetamol: exhibits analgesic action of peripheral blockage of pain impulse generation. It produces antipyresis by inhibiting the hypothalamic heat regulating centre. Its weak anti-inflammatory activity is related to inhibition of prostaglandin synthesis in the CNS.

Side Effects

GI disturbances, nephrotic syndrome, epigastric pain, nausea, vomiting, diarrhea, hepatitis, rash, pruritus, wheezing, bronchospasm, prolonged bleeding time.

Contraindications

Hypersensitivity, active peptic ulcer or GI bleeding, history of allergic responses to aspirin or other NSAIDs, acute porphyria.

Observations

None