Rufenac

Posted September 23, 2018

Rufenac

Rufenac is used in the treatment of pain and inflammation of various origins, Diclofenac is used to treat mild to moderate pain & inflammations

Product	Molecule
Rufenac Gel	Diclofenac Sodium, Methyl Salicylate, Menthol
Rufenac Tablets	Diclofenac Sodium

Molecule: Diclofenac Sodium, Methyl Salicylate, Menthol

Formulation: Diclofenac Sodium 1.0% w/w + Methyl Salicylate 3.0% w/w + Menthol 2.0 % w/w Topical Gel

Packaging Unit: 30gm Gel

Dosage: For local symptomatic relief of pain and inflammation (1% gel): Apply onto affected area 3-4 times daily.

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Molecule: Diclofenac Sodium

Formulation: Diclofenac Sodium 50mg Tablets

Packaging Unit: 25X10 Tablets

Dosage: Adults: 75-150 mg daily in divided doses. Max: 150 mg/day.

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Indications

For relief of the signs and symptoms of osteoarthirits, rheumatoid arthritis and ankylosing spondylitis.

Pharmacological Class

Diclofenac: benzene-acetic acid derivative.

Pharmacological Properties

Anti-inflammatory, analgesic

Mechanism Of Action

Diclofenac Inhibits cyclooxygenase (COX)-1 and COX-2, thereby inhibiting prostaglandin synthesis. May also inhibit neutrophil aggregation/activation, inhibit chemotaxis, decrease proinflammatory cytokine level, and alter lymphocyte activity.

Side Effects

GI disturbances, headache, dizziness, rash, GI bleeding, peptic ulceration, abnormalities of kidney function.

Contraindications

Active peptic ulcer; hypersensitivity to diclofenac or other NSAIDs. Treatment of perioperative pain in CABG surgery. 3rd trimester of pregnancy. Topical: Not to be applied onto damaged or nonintact skin.

Observations

Renal function may be worsened when used with ciclosporin or triamterene. Altered absorption when given with sucralfate, colestyramine or colestipol. Increased risk of GI ulceration and bleeding when used with corticosteroids, aspirin or anticoagulants.