Rufenac is used in the treatment of pain and inflammation of various origins, Diclofenac is used to treat mild to moderate pain & inflammations
|Diclofenac Sodium, Methyl Salicylate, Menthol
Molecule: Diclofenac Sodium, Methyl Salicylate, Menthol
Formulation: Diclofenac Sodium 1.0% w/w + Methyl Salicylate 3.0% w/w + Menthol 2.0 % w/w Topical Gel
Packaging Unit: 30gm Gel
Dosage: For local symptomatic relief of pain and inflammation (1% gel): Apply onto affected area 3-4 times daily.
Molecule: Diclofenac Sodium
Formulation: Diclofenac Sodium 50mg Tablets
Packaging Unit: 25X10 Tablets
Dosage: Adults: 75-150 mg daily in divided doses. Max: 150 mg/day.
For relief of the signs and symptoms of osteoarthirits, rheumatoid arthritis and ankylosing spondylitis.
Diclofenac: benzene-acetic acid derivative.
Mechanism Of Action
Diclofenac Inhibits cyclooxygenase (COX)-1 and COX-2, thereby inhibiting prostaglandin synthesis. May also inhibit neutrophil aggregation/activation, inhibit chemotaxis, decrease proinflammatory cytokine level, and alter lymphocyte activity.
GI disturbances, headache, dizziness, rash, GI bleeding, peptic ulceration, abnormalities of kidney function.
Active peptic ulcer; hypersensitivity to diclofenac or other NSAIDs. Treatment of perioperative pain in CABG surgery. 3rd trimester of pregnancy. Topical: Not to be applied onto damaged or nonintact skin.
Renal function may be worsened when used with ciclosporin or triamterene. Altered absorption when given with sucralfate, colestyramine or colestipol. Increased risk of GI ulceration and bleeding when used with corticosteroids, aspirin or anticoagulants.