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Rufenac

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Rufenac

Rufenac is used in the treatment of pain and inflammation of various origins, Diclofenac is used to treat mild to moderate pain & inflammations
Product Molecule
Rufenac Gel
Diclofenac Sodium, Methyl Salicylate, Menthol
Rufenac Tablets
Diclofenac Sodium
Indications
For relief of the signs and symptoms of osteoarthirits, rheumatoid arthritis and ankylosing spondylitis.
Pharmacological Class
Diclofenac: benzene-acetic acid derivative.
Pharmacological Properties
Anti-inflammatory, analgesic
Mechanism Of Action
Diclofenac Inhibits cyclooxygenase (COX)-1 and COX-2, thereby inhibiting prostaglandin synthesis. May also inhibit neutrophil aggregation/activation, inhibit chemotaxis, decrease proinflammatory cytokine level, and alter lymphocyte activity.
Side Effects
GI disturbances, headache, dizziness, rash, GI bleeding, peptic ulceration, abnormalities of kidney function.
Contraindications
Active peptic ulcer; hypersensitivity to diclofenac or other NSAIDs. Treatment of perioperative pain in CABG surgery. 3rd trimester of pregnancy. Topical: Not to be applied onto damaged or nonintact skin.
Observations
Renal function may be worsened when used with ciclosporin or triamterene. Altered absorption when given with sucralfate, colestyramine or colestipol. Increased risk of GI ulceration and bleeding when used with corticosteroids, aspirin or anticoagulants.
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