Ceftriaxone and tazobactum synergistic combination provides excellent results in the management of severe and resistant infections
Shalbactam TZ Injectables
Molecule: Ceftriaxone, Tazobactam
Formulation: Ceftriaxone 1g + tazobactam 125mg / 5ml VIAL
Packaging Unit: 1 Vial
Dosage: Adults: the usual adult daily dose of shalbactam tz is 1.125 to 2.250 grams given once a day (or in equally divided doses twice a day) depending on the type and severity of infection. The total daily dose should not exceed 4.5 grams. For preoperative use (surgical prophylaxis), a single dose of 1.125 gm administered intravenously ½ to 2 hours before surgery is recommended. Pediatric patients: The usual pediatric daily dose of shalbactam tz is 50 to 75mg/kg given once a day (or in equally divided doses twice a day) depending on the type and severity of infection. The usual duration of therapy is 7 to 14 days.
Infections caused by the susceptible organisms in bacterial meningitis, bone and joint infections, community-acquired pneumonia, intra-abdominal infections, lower respiratory tract infections, pelvic inflammatory disease, uncomplicated gonorrhoea, skin and skin structure infections, bacterial septicaemia, urinary tract infections.
Mechanism Of Action
Ceftriaxone interferes with the biosynthesis of the peptidoglycan component of the bacterial cell way by binding to and inactivating penicllin-binding proteins (pbps). Tazobactam is a penicillanic acid sulfone derivative with β-lactamase inhibitory properties. It enhances the activity of β-lactam antibacterials against β-lactamase-producing bacteria.
Hypersensitivity to cephalosporins and b-lactamase inhibitors.