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Shalflod

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Shalflod

Shalflod is indicated for empirical treatment of mixed aerobic-anaerobic infections in sensitive organisms, commonly seen in clinical practice
Product Molecule
Shalflod Infusion
Ofloxacin, Ornidazole
Shalflod Suspension
Ofloxacin, Ornidazole
Shalflod Tablets
Ofloxacin, Ornidazole
Indications
Oflodazole is indicated for empirical treatment of mixed aerobic-anaerobic infections in sensitive organisms, commonly seen in clinical practice e.g. intra-abdominal infection, gynaecological and pelvic infections, foot ulcers especially in diabetes, lung abscess, infections in immuno-compromised patients.
Pharmacological Class
Pharmacological Properties
Mechanism Of Action
Ofloxacin: It inhibits bacterial DNA replication by blocking DNA topo-isomerases, in particular DNA gyrase. Ornidazole: After passive absorption into bacterium cell, the nitro group of Ornidazole is reduced to amine group by ferrodoxin type redox system. The formation of redox intermediate intracellular metabolites is believed to be the key component of microorganism killing for Ornidazole.
Side Effects
Contraindications
Ofloxacin: Ofloxacin should not be used in patients with known hypersensitivity to 4-quinolone antibacterial or any of the tablet excipients. Ofloxacin should not be used in patients with a past history of tendinitis. Ofloxacin, like other 4-quinolones, is contra-indicated in patients with a history of epilepsy or with a lowered seizure threshold. Patients with latent or actual defects in glucose-6-phosphate dehydrogenase activity may be prone to haemolytic reactions when treated with quinolone antibacterial agents. Ornidazole: Ornidazole should not be used in patients with known hypersensitivity to Ornidazole or any component of this formulation or with active renal disease or hepatic cirrhosis.
Observations
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