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Shalflox

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Shalflox

Norfloxacin is an oral broad-spectrum antibacterial agent used in the treatment of urinary tract infections and stomach infections
Product Molecule
Shalflox M Suspension
Norfloxacin, Metronidazole
Shalflox M Tablets
Norfloxacin, Metronidazole
Shalflox Tablets
Norfloxacin
Indications
Shalflox 400 is indicated for the treatment of adults with the following infections caused by susceptible strains of the designated microorganisms: Urinary tract infections: Uncomplicated urinary tract infections (including cystitis) due to Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus epidermidis, Staphylococcus saprophyticus, Citrobacter freundii, Enterobacter aerogenes, Enterobacter cloacae, Proteus vulgaris, Staphylococcus aureus, or Streptococcus agalactiae. Complicated urinary tract infections due to Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, or Serratia marcescens. Sexually transmitted diseases: Uncomplicated urethral and cervical gonorrhea due to Neisseria gonorrhoeae and Prostatitis due to Escherichia coli.
Pharmacological Class
Norfloxacin: Fluoroquinolone.
Pharmacological Properties
Antibiotic
Mechanism Of Action
Shalflox 400 is one of most active fluoroquinolone and acts by inhibiting bacterial DNA gyrase. Its spectrum includes both gram-ve and gram+ve organisms including Enterobacteriaceae, Haemophilus, Neisseriae and Pseudomonas, Penicillinase producing and methicillin resistant staphylococci.
Side Effects
Rare: Nausea, headache and dizziness.
Contraindications
Shalflox 400 is contraindicated in persons with a history of hypersensitivity, tendinitis, or tendon rupture associated with the use of norfloxacin or any member of the quinolone group of antimicrobial agents.
Observations
No significant lethality was observed in male and female mice and rats at single oral doses up to 4 g/kg. In the event of acute overdosage, the stomach should be emptied by inducing vomiting or by gastric lavage, and the patient carefully observed and given symptomatic and supportive treatment. Adequate hydration must be maintained.
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