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Sunat A

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Sunat A

Sunat A is a therapy indicated for the treatment of all forms of malaria, including multi drug-resistant strains
Product Molecule
Sunat A Forte Tablets
Artesunate, Amodiaquine
Sunat A Tablets
Artesunate, Amodiaquine
Indications
Treatment of uncomplicated P. falciparum malaria.
Pharmacological Class
Artesunate: Artemisinin derivative. Amodiaquine: 4-amino quinoline derivative.
Pharmacological Properties
Mechanism Of Action
The functional group responsible for antimalarial activity of Artesunate is endoperoxide bond. Release of an active oxygen species from this bond kills the parasite if accumulated in the erythrocytic cells. Amodiaquine accumulates in the lysosomes and brings about loss of function.
Side Effects
Agranulocytosis and other blood dyscrasias, hepatitis and peripheral neuropathy have been reported occasionally after Amodiaquine usage alone. Administration of quinoline type drugs has been associated with hemolytic anaemia. Dizziness, itching, vomiting, abdominal pain, flatulence, headache, body ache, diarrhoea, tinnitus, increased hair loss, macular rash, reduction in neutrophil counts and convulsions.
Contraindications
Known hypersensitivity to Amodiaquine or 4 - amino quinolines and Artesunate or Artemisinin derivatives. Because of resistance and risk of major toxicity, Amodiaquine is not recommended for the prophylaxis of malaria. Amodiaquine is also contraindicated in patients with hepatic disorders.
Observations
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