Depression Medication Supplement

Overcoming the side effects of anti-depressant medication

Prescription medication for the treatment of depression

Depression is a common medical condition that has a big impact on a large number of areas in patients’ lives4.

A class of medication that is currently commonly used in the treatment of depression is called a selective serotonin reuptake inhibitor, or an SSRI for short. It helps to keep serotonin more available for uptake and use by the brain4.

Essential nutrients in the management of depression

Besides the SSRIs, essential nutriants such as folate, vitamin D and vitamin B12 also play a crucial role in the management of depression. Low levels of these nutrients are also associated with poor response to antidepressant treatment2, 3, 5, 6.

Folate helps with the production of important role players (for example noradrenaline) that are responsible for enhancing mood6.

Vitamin B12 helps our neurological system (brain and nervous system) function optimally and may contribute towards a better response to anti-depressant medication when used in combination3, 6.

In terms of reducing inflammation, vitamin D is the key role player and may also assist in a better response towards anti-depressant therapy2.

Nutrient depletion

These 3 essential nutrients may however be depleted as a result of depression or the treatment thereof1, 5.

SSRI-GAP capsules, taken once daily, contain folate, vitamin B12 and vitamin D in order to ensure that any deficiency is overcome, that mood is improved, and that the response to and outcome towards anti-depressant treatment is optimal1.

Depression Medication Supplement


Depression is common and has significant impact1

< 40 % of patients treated with SSRIs, the most commonly used antidepressant monotherapy, achieve full remission3

Although the strategy of adding a second antidepressant may enhance efficacy, it comes with the risk of reduced tolerability3

Depression Medication Supplement

South Africans in the workplace suffer from depression1

Depression Medication Supplement

age group is most commonly affected, which represents the economic engine of the country1

Depression Medication Supplement

taken off work during the last depressive episode1

Depression Medication Supplement

of the total cost of depression in the US is attributable to workplace costs*1

Depression Medication Supplement
Depression Medication Supplement

To read more about depression, click “here

Role of folate, vitamin D & vitamin B12 in depression

Physiological effects of folate, vitamin D & vitamin B12 in depression


SSRI-GAP assists in the maintenance of the essential nutrients that may be  depleted as a result of depression and the treatment thereof8


SSRI-GAP assists in the maintenance of the essential
nutrients that may be depleted as a result of depression
and the treatment thereof

Dosage & directions for use

Take one (1) capsule daily8

Please note: This is an educational information leaflet only and should not be used for diagnosis. For more information on depression, consult your healthcare professional.

Introduction references:

  1. SSRI-GAP approved package insert, Adcock, 2017
  2. Haixia Shi, Antidepressant Effect of Vitamin D: A Literature Review, Literature review, Neuropsychiatry, 2017
  3. Ehsan Ullah Syed, Vitamin B12 Supplementation in Treating Major Depressive Disorder: A Randomized Controlled Trial, Open Neurol J. 2013; 7: 44–48
  4. NHS, An overview of SSRIs, Nov 1, 2018
  5. Hyla Cass, M.D., A Practical Guide to Avoiding Drug-Induced Nutrient Depletion, Nutrition Review. Aug 23, 2018
  6. Coppen A, Treatment of depression: time to consider folic acid and vitamin B12, J Psychopharmacol. 2005 Jan;19(1):59-65.

Further references:

1. Stander MP, Bergh M, Miller-Janson HE, et al. Depression in the South African workplace. S Afr J Psychiat 2016;22(1):a814. http://dx.doiorg/10.4102/sajpsychiatry.v22i1.814.

2. Coppen A, Bolander-Gouaille C. Treatment of depression: time to consider folic acid and vitamin B12. J Psychopharmacol 2005;19(1):59-65.

3. Morris DW, Trivedi MH, Rush AJ. Folate and unipolar depression. J Alt Comp Med 2008;14(3):277-285.

4. Roberts SH, Bedson E, Hughes D, et al. Folate augmentation of treatment – evaluation for depression (FolATED): protocol of a randomised controlled trial. BMC Psychiatry 2007;7:65. Doi:10.1.186/1471-244X-7-65.

5. Milaneschi Y, Hoogendijk W, Lips P, et al. The association between low vitamin D and depressive disorders. Molec Pscyhiatr 2014;19:444-451.

6. Khoraminya N, Tehrani-Doost M, Jazayeri S, et al. Therapeutic effects of vitamin D as adjunctive therapy to fluoxetine in patients with major depressive disorder. ANZJP 2012;47(3):271-275.

7. Syed EU, Wasay M, Awan S. Vitamin B12 supplementation in treating
major depressive disorder: a randomized controlled trial. Open Neurol J 2013;7:44-48.

8. SSRI-GAP approved package insert, 2017.

9. Ross CA, Taylor CL, Yaktine AL, et al (eds). Dietary Reference Intakes (DRIs): Dietary reference intakes for calcium and vitamin D. Institute of Medicine, National Academy of Sciences, 2011. [cited 2017 Apr 08]; Available from: https://www.nap.edu/13050.

10. Ferder M, Inserra F, Manucha W. The world pandemic of vitamin D deficiency could possibly be explained by cellular inflammatory response activity induced by the renin-angiotensin system. Am J Physiol Cell Physiol 2013;304:C1027-C1039.

11. Vitamin B12 – health professional fact sheet. NIH Office of Dietary Supplements, 2016. [cited 2017 Apr 08]; Available from: https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/.

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Depression Medication Supplement

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