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Diabetes Medication Supplement

Overcoming the side effects of diabetic medication

Patients with Type 2 Diabetes Mellitus requires chronic medication to lower their blood glucose (sugar) levels, as chronically elevated blood glucose levels can cause damage to organs, systems, tissues and cells over time.1, 2
Diabetic patients must however realise that essential nutrients may be depleted as a result of diabetes and the treatment thereof.3, 10

The Solution
GLUCO-GAP provides the all-in-one solution for supplementing essential nutrients, with just one capsule per day.3

It contains Coenzyme Q10 (in the form of HydroQsorb CoQ10 for more efficient cellular uptake) which is a potent anti-oxidant that improves blood glucose- and cholesterol control.4, 5, 7 In addition, the Chromium in the formulation has a beneficial effect on insulin resistance.3, 5, 6, 8

Vitamin B1 assists with the maintenance of healthy blood vessels, thereby decreasing the risk for developing heart disease or stroke.5, 6, 10

Vitamin B12 deficiency is also often found to be associated with the dosage and duration of diabetic medication use. This crucial vitamin is needed for nerve tissue health, brain function, and the production of red blood cells, and therefore also incorporated into GLUCO-GAP.3, 6, 10

Last but definitely not least, it also includes vitamin D to help prevent glucose increases, prevent insulin resistance, enhance insulin sensitivity and reduce blood pressure in patients with diabetes.3, 6, 9

Diabetes Medication Supplement

For more information on Diabetes, click “here

Diabetes

A serious chronic disease – is on the rise. Globally, 422 million adults living with diabetes in 20141

Diabetes Medication Supplement
Diabetes Medication Supplement
Diabetes Medication Supplement
Diabetes Medication Supplement

Effect of physiological effects and deficiency

Diabetes Medication Supplement

PHYSIOLOGICAL EFFECTS

Improves glycaemic control by improving insulin secretion & as well as total and low density lipoprotein (LDL) cholesterol levels3

DEFICIENCY

Q10 levels, can be used as a marker of antioxidant capacity, and is decreased in diabetic patients3

Diabetes Medication Supplement

PHYSIOLOGICAL EFFECTS

Beneficial effect of chromium in insulin resistance3

Diabetes Medication Supplement

PHYSIOLOGICAL EFFECTS

Could play a role in improving endothelial function and thus slow development and progression of atherosclerosis3

Diabetes Medication Supplement

DEFICIENCY

The vitamin B12 deficiency is found to be associated with the dosage and duration of metformin use3

Diabetes Medication Supplement

PHYSIOLOGICAL EFFECTS

Vitamin D levels of at least 30 ng/ml needs to be maintained to prevent glucose increases, prevent insulin resistance, enhance sensitivity and reduce blood pressure in patients with diabetes3

DEFICIENCY

Prevalent in patients with diabetes and an independent association between vitamin D deficiency and the presence of nephropathy3

Diabetes Medication Supplement

Cellular Uptake

GLUCO-GAP contains HydroQsorb CoQ10 for more efficient cellular uptake4

HydroQsorb is incorporated more efficiently at 72 % vs. 52 % for control CoQ104

  • Micellarisation is a critical step in the absorptive process
  • CoQ10 is hydrophobic and will pass through the intestine unabsorbed if not incorporated into micelles

The tissue incorporation of 50 mg HydroQsorb CoQ10 is equivalent to that of 200 mg of CoQ104

GLUCO-GAP contains HydroQsorb CoQ10 for more efficient cellular uptake4

HydroQsorb’s cellular uptake is 4.9 times higher vs. CoQ10 control4

  • The next step in absorption is uptake of micelles by intestinal cells
  • Enhanced uptake of HydroQsorb allows for lower dosages to accomplish the same degree of tissue incorporation

The tissue incorporation of 50 mg HydroQsorb CoQ10 is equivalent
to that of 200 mg of CoQ104

GLUCO-GAP

GLUCO-GAP assists in the maintenance of the essential nutrients that may be depleted as a result of diabetes and the treatment thereof3

Diabetes Medication Supplement

AMOUNT PER GLUCO-GAP CAPSULE (DOSAGE: 1 CAPSULE DAILY)3

50 mg

DRI (DIETARY REFERENCE INDEX)5**

30 – 200 mg5

OTHER SOURCES

Small amounts in fish, meats and wholegrains but not enough to sufficiently boost coenzymes Q10 levels7

Diabetes Medication Supplement

AMOUNT PER GLUCO-GAP CAPSULE (DOSAGE: 1 CAPSULE DAILY)3

0.025 mg

DRI (DIETARY REFERENCE INDEX)5**

Men > 70 years:
30 μg/day 0.03 mg6

Women > 70 years:
20 μg/day 0.02 mg6

OTHER SOURCES

Carrots, potatoes, broccoli, wholegrains, and molasses8

Diabetes Medication Supplement

AMOUNT PER GLUCO-GAP CAPSULE (DOSAGE: 1 CAPSULE DAILY)3

800 IU

DRI (DIETARY REFERENCE INDEX)5**

Men and women
≤ 70 years: 600 IU/day6

Men and women
> 70 years: 800 IU/day6

OTHER SOURCES

Sunlight, oily fish, fortified food9

Diabetes Medication Supplement

AMOUNT PER GLUCO-GAP CAPSULE (DOSAGE: 1 CAPSULE DAILY)3

0.1 mg

DRI (DIETARY REFERENCE INDEX)5**

*Men:
2.4 μg/day 0.024 mg6

*Women:
2.4 μg/day 0.024 mg6

OTHER SOURCES

Meats (especially beef, pork and liver), poultry, eggs, fortified cereals, milk and milk products, clams, oysters, mackerel, salmon10

Diabetes Medication Supplement

AMOUNT PER GLUCO-GAP CAPSULE (DOSAGE: 1 CAPSULE DAILY)3

5 mg

DRI (DIETARY REFERENCE INDEX)5**

Men: 1.2 mg/day6
Women: 1.1 mg/day6

OTHER SOURCES

Whole grains, meats (especially pork and liver), enriched cereal products, nuts, legumes, potatoes10

Dosage & directions for use

Take one (1) capsule daily3

Please note: This is an educational information leaflet only and should not be used for diagnosis. For more information on diabetes, consult your healthcare professional.

1. Global Report on Diabetes. World Health Organization 2016. [cited 2017 April 10]; Available from: http://www.who.int/diabetes/global-report/en/

2. Amod A, Ascott-Evans BH, Berg GI et al. The 2012 SEMDSA Guideline for the management of type 2 diabetes (revised). JEMDSA 2012;(Supplement 1):S1-S95.

3. GLUCO-GAP approved package insert, 2017..

4. Craft NE and Failla M. In vitro assessment of coenzyme Q10 bioavailability in three
products using caco-2 cells. Final report, Tishcon Corp 2006.

5. NUTRI-FACTS understanding vitamins & more.
Coenzyme Q10. [cited 2017 April 10]; Available from http://www.nutri-facts.org/en_US/nutrients/nutraceuticals/coenzyme-q10.htm

6. Ross CA, Taylor CL, Yaktine AL, et al (eds). Dietary Reference Intakes (DRIs): Dietary reference intakes for calcium and vitamin D. Institute of Medicine, National Academy of Sciences, 2011. [cited 2017 April 10];
Available from: https://www.nap.edu/13050

7. Coenzyme Q10 (CoQ10): In depth. [cited 2017 April]; Available from: https://nccih.nih.gov/health/supplements/coq10.

8. Chromium. Merck Manuals Professional Version. [cited 2017 May 23] available at http://www.merckmanuals.com/professional/special-subjects/dietary-supplements/chromium

9. Federer M, Inserra F, Manucha W. The world pandemic of vitamin D deficiency could possibly be explained by cellular inflammatory response activity induced by the renin-angiotensin system. Am J Physiol Cell Physiol 2013;304:c1027-c1039.

10. Overview of Vitamins – Nutritional Disorders – Merck Manuals Professional Edition. Source, Functions and Effects of Vitamins. [cited 2017 May 19] available at http://www.merckmanuals.com/professional/nutritional-disorders/vitamin-deficiency

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