Glibenclamide 5mg Tablets
In general the initial dose is half a tablet (2.5mg Gliben) daily. The daily dose can then be raised gradually in steps of half a tablet, but only after repeating medical examination. Raising the dose beyond 15mg daily does not usually produce any increased response. When changing over from another oral antidiabetic preparation, with a similar mode of action, the dosage of Gliben is determined by the amount of the previously administered dose and the medical examination. It may be considered that the effect of 1g tolbutamide or glycodiazine, 0.5g carbutamide or 250mg chlorpropamide corresponds roughly to that of 5mg Gliben (1 tablet). In combination therapy with a biguanide, there may be a greater risk of cardiovascular mortality than with the use of glibenclamide alone.